Home » Page 6

Quote of the Day:

In music the passions enjoy themselves.
- Friedrich Nietzsche

DMV, Avastin and Physical Therapy

Chemotherapy 3 Comments »

Today I have the pleasure of feeling like I’m sixteen years old again and driving around with a DMV examiner sitting in my car, clipboard in hand and watching my every move to determine whether or not it’s safe for me to be on the road with the rest of the population.  My toes on my left foot are paralyzed – this could present grave danger.  Well, in all seriousness, I do understand the situation so it’s fine with me. 

I was thinking about it and figured it will be a snap but after second-guessing myself, I decided to go out to youtube and search on CA DMV Road Test or something like that.  Turns out they have a Top 10 Reasons You Fail Video list!  It’s not so bad – silly things but errors we all make every day as burned-in drivers.  Take a lane change for example - according to the DMV, if you don’t a) turn on your signal, b) check your mirrors (plural – rear view and side), and c) check you blind spot, you have commited the dreaded CRITICAL error.  Regardless of how well you do before or after this tragic error in judgment, you’ve completely blown it my friend.  Game over.  Done.  You have FAILED the test.  Huh.  I guess it’s not that easy after all?  Do you think I might be able to just tell them I had brain surgery so I left one of the steps out accidentally and I’m sorry about that?!  Probably not I suppose.

Quite seriously, I was astonished looking at this stuff because after decades of driving you just don’t think about everything in the way they really want you to.  So, back to the drawing board.  And, I don’t have a front license plate on my car but the list on the site says you better have one.  I’ll find it I hope!

The avastin seems to really be showing some results.  After my first infusion, I had physical therapy a few days later and we noticed that my gait was more improved.  The session after that showed even more substantial improvement – improved heel striking, less rolling, etc.  I’m walking more without the brace around the house and over the last week left the cane at home.  That’s quite a change in a short time.  My physical therapy appointment yesterday was also very good.  I’m just making steady progress and working hard but I can now see that since I’ve started the avastin infusions, there has been significant improvement at a much faster pace.  

As I posted previously, I had another infusion last week and will have another on the 30th.  My oncologist said that if you are going to respond it will happen quickly – you will show improvement in ways such as this.   When she first asked me how I felt after the first infusion I said fine – she asked me if I felt anything at all and I said “no?”.  I thought she was referring to side effects – she was fishing for this info. 

This is great news but also means we will have some decisions to make here soon.  Since it appears I am responding so well to avastin, do you try to fix what isn’t broken?  Probably not – meaning, do we pull avastin in favor of the vaccine.  I think everyone would agree that we should not do that.  So, the strategy would be to carry out the leukapheresis and use cryogenics to freeze this indefinitely if necessary.  If Avastin fails, we can pull the vaccine and implement it – for those of you that have been reading you are familiar with this whole strategy.

That is really all for now.  Today is Driving Ms. Daisy then I’ll finish up work tomorrow, hopefully with a driver’s license!  We’ll close the office around Noon so it will be an easy day.  I’ll be off for the holiday until Monday then it’s time for football.

The best Bowl game this year?  The ROSE BOWL!  USC vs. Penn State.  My prediction?  USC 31 Penn State 14.  That one is for you John Estes because I know you will be watching

For the record, I think USC would hammer the Sooners or Gators.  Too bad we can’t see one of those games happen – why can’t they come up with a playoff system?  Could you imagine if at the end of the NBA season a bunch of computers decided that the Lakers and Suns should play for the “NBA Championship” and left out every other team in the NBA??  All based on a bunch of metrics like strength of schedule, points for, against, their opponents’ opponents?  I could write an entire post about this, put up a system they could use, etc. etc. but alas, no time. 

Cheers,

Subscribe by EmailSubscribe by Email RSS Subscription RSS Subscription

  • Share/Bookmark

Started Avastin

Chemotherapy 3 Comments »

More on the DVax-Brain vaccine saga in a moment, but put shortly my slot is set to start in the first week of January which for a Glioblastoma Multiforme patient is an eternity from my surgery date of 10/15/08.  Therefore, I can’t stand around for that long and leave this untreated for that long.  There are people with GBMs that die in 3 months if they don’t treat these tumors quickly!  We had to wait 4 weeks which is standard but we are coming up on 8 weeks past that period.

So, I have started using Avastin and had my first infusion on Tuesday and I will receive an infusion every 2 weeks.  It’s an IV-based therapy that was first approved in 2004 for metastic cancers (cancers that have spread to other parts of the body).  Colon cancer and non-small cell lung cancer were the first followed by breast cancer in 2008.

Avastin has shown to be very effective in treating GBMs.  Put simply, it works by inhibiting tumor growth by blocking the formation of new blood vessels (angiogenesis) and was the first clinically available angiogenesis inhibitor in the United States.

Updated:  Here is a great article that ran in the Wall Street Journal about Avastin. The same article appeared on Virtual Trials as an embedded article on their site.  What is amazing is that last night I received an email from the editor of the Wall Street Journal health blog telling me to take down the article as an embedded article, that I am reproducing their site in my site and it’s not allowed.  Placing a link is fine but putting the site in an iframe, in spite of the fact that all of their advertisement, links and authorship credits (i.e. I’m not stealing anything) and anything else they place on the site are all in tact is not OK with them.  This is all going on while VirtualTrials.com has conducted the same practice via the link above since 11/5/08.  I posted this yesterday and received an email the same day asking that I pull it down.  Such is the ins and outs of the legal world but it was very surprising – I’m a fairly small concern here!

Here are links to both articles on the Wall Street Journal site:

Genetech Seeks FDA Nod For Avastin For Brain Cancer

Targeted Drugs Take a Crack At Brain Cancer

My insurance company has been terrific.  I have not received a single denial of coverage.  Avastin is $10K+ per infusion and I will receive one every 2 weeks.  Since the first infusion on Wednesday, I have had ZERO side effects which is great.  I went back to work on Tuesday as you know and had a normal day on Thursday and Friday so I’m thrilled.

When the vaccine is available, we can take advantage or if I am really responding well to Avastin, we can add another agent on top of Avastin and use cryogenics to preserve the vaccine and implement later.  The issue with the vaccine (the current issue – new issue, whatever you want to call it) is we didn’t know we needed a “slot” with the lab.  Apparently we do which, as I said, is January.  It’s really turned into a learn/become informed as we go situation which is unfortunate when your life is on the line.  So, we have to go on to other solutions for now.

That’s it for now.  We celebrate Christmas so the tree is in our house.  Our good friend Tom and his wife came by and he was kind enough to climb the pull-down attic ladder and retrieve our bins of decorations so we should have everything up pretty soon!  The Holidays will be great and we are really looking forward to them.

More soon…

Subscribe by EmailSubscribe by Email RSS Subscription RSS Subscription

  • Share/Bookmark
   © 2010 Mark L. Miller, All Rights Reserved
   www.markmillermusic.org / Site Map